منابع مشابه
Lung collagen heterogeneity. Synthesis of type I and type III collagen by rabbit and human lung cells in culture.
The fetal and adult lung have a constant level of collagen synthesis that represents 4-5% of the total amino acids incorporated into lung protein. Prior studies have demonstrated that this collagen is not homogeneous but rather is composed of at least two collagen types, I and II, each localized to specific lung structures. Although it is known that explants of rabit lung parenchyma and blood v...
متن کاملChanges in the fatty acid composition and hydroxyproline content in rat lung in relation to collagen synthesis after paraquat administration.
OBJECTIVES Effect of paraquat on the fatty acid composition (weight percentage) of rat lung was studied with particular reference to the change of hydroxyproline content in the course of paraquat-induced dysfunction and subsequent repair. METHODS Eight-week-old male Wistar rats were administered paraquat at 20 mg/kg body weight subcutaneously, and the wet weight, hydroxyproline content and fa...
متن کاملCollagen chain composition and collagen gene expression in acne keloids.
Keloids are thick scars that grow beyond the boundaries of the original skin damage. Most lesions appear within one year of skin inflammation including burns, surgery and acne vulgaris. They are characterized by an excessive accumulation of extracellular mamx components. Keloid waning results from increased activity of fibroblasts in the dermis with imbalance between synthesis and breakdown of ...
متن کامل[Collagen synthesis and heart failure].
Little is known about collagen metabolism in heart failure, with or without left ventricular systolic dysfunction. We studied serum concentrations of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of collagen type-I synthesis, and of the carboxy-terminal telopeptide of collagen type I (ICTP), a marker of collagen type-I degradation, in 70 patients admitted for heart failu...
متن کاملEffect of gamma-interferon on collagen synthesis by normal and fibrotic human lung fibroblasts.
Increased lung collagen and increased collagen synthesis by lung fibroblasts is well recognized in pulmonary fibrosis. gamma-Interferon has been shown to inhibit collagen synthesis by fibroblasts. To understand its effect on lung fibroblasts we compared how this lymphokine affects the growth and collagen synthesis of normal and fibrotic human lung fibroblasts. The results showed that gamma-IFN ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42682-3